The Bess Lab

Discovering & Engineering Microbiome Chemistry 


18. Maini Rekdal, V.; Bernadino, P. N.; Luescher, M. U.;  Kiamehr, S.;  Le, C.;  Bisanz,  J. E.;  Turnbaugh, P. J.;  Bess, E. N.;  Balskus, E. P. A Widely Distributed Metalloenzyme Class Enables Gut Microbial Metabolism of Host- and Diet-Derived Catechols. eLife20209, e50845.

Postdoctoral Work:

17. Bisanz, J. E.; Soto-Perez, P.; Noecker, C.; Aksenov, A.; Lam, K. N.; Kenney, G. E.; Bess, E. N.; Haiser, H. J.; Kyaw, T. S.; Yu, F. B.; Rekdal, V. M.; Ha, C. W. Y.; Devkota, S.; Balskus, E. P.; Dorrestein, P. C.; Allen-Vercoe, E.; Turnbaugh, P. J. A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria. Cell Host Microbe 2020, 27, 1001-1013.e9.

16. Bess, E. N.; Bisanz, J.; Yarza, F.; Bustion, A.; Rich, B. E.; Li, X.; Kitamura, S.; Waligurski, E.; Ang, Q. Y.; Alba, D. L.; Spanogiannopoulos, P.; Nayfach, S.; Koliwad, S. K.; Wolan, D. W.; Franke, A. A.; Turnbaugh, P. J. Genetic Basis for the Cooperative Bioactivation of Plant Lignans by Eggerthella lenta and Other Human Gut Bacteria. Nature Micro. 2020, 5, 56–66.

15. Carmody, R.; Bisanz, B.; Bowen, B.; Maurice, C.; Lyalina, S.; Louie, K.; Treen, D.; Chadaideh, K.; Rekdal, V.; Bess, E. N.; Spanogiannopoulos, P.; Ang, Q. Y.; Bauer, K.; Balon, T.; Pollard K.; Northen, T.; Turnbaugh, T. Cooking Shapes the Structure and Function of the Gut Microbiome. Nature Micro. 2019, 4, 2052–2063.

14. Maini Rekdal, V.; Bess, E. N.; Bisanz, J. E.; Turnbaugh, P. J.; Balskus, E. P. Discovery and Inhibition of an Interspecies Gut Bacterial Pathway for Levodopa Metabolism. Science 2019364, eaau6323.

13. Spanogiannopoulos, P.; Bess, E. N.; Carmody, R. N.; Turnbaugh, P. J. The Microbial Pharmacists Within: A Metagenomic View of Xenobiotic Metabolism. Nature Rev. Microbiol. 2016, 14, 273–287.

Graduate Work:

12. Sigman, M. S.; Harper, K. C.; Bess, E. N.; Milo, A. The Development of Multidimensional Analysis Tools for Asymmetric Catalysis and Beyond. Acc. Chem. Res. 2016, 49, 1292–1301.

11. Mougel, V.; Santiago, C. B.; Zhizhko, P. A.; Bess, E. N.; Varga, J.; Frater, G.; Sigman, M. S.; Coperet, C. Quantitatively Analyzing Metathesis Catalyst Activity and Structural Features in Silica-Supported Tungsten Imido-Alkylidene Complexes. J. Am. Chem. Sci. 2015, 137, 6699–6704.

10. Bess, E. N.; Guptill, D.; Davies, H. M. L.; Sigman, M. S. Using IR Vibrations to Quantitatively Describe and Predict Site-Selectivity in Multivariate Rh-Catalyzed C–H Functionalization. Chem. Sci. 2015, 6, 3057–3062.

9. Bess, E. N.; Bischoff, A. J.; Sigman, M. S. Designer Substrate Library for Quantitative, Predictive Modeling of Reaction Performance. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 14698–14703.

8. Bess, E. N.; DeLuca, R. J.; Tindall, D. J.; Oderinde, M. S.; Roizen, J. L.; Du Bois, J.; Sigman, M. S. Analyzing Site Selectivity in Rh2(esp)2-Catalyzed Intermolecular C–H Amination Reactions. J. Am. Chem. Soc. 2014, 136, 5783–5789.

7. Milo, A.; Bess, E. N.; Sigman, M. S. Interrogating Selectivity in Catalysis using Molecular Vibrations. Nature 2014, 507, 210–214.

6. Bess, E. N.; Sigman, M. S. Distinctive Meta-Directing Group Effect for Iridium-Catalyzed 1,1-Diarylalkene Enantioselective Hydrogenation. Org. Lett. 2013, 15, 646–649. Highlighted in Angew. Chem. Int. Ed. 2013, 52, 8795-8797.

5. Bess, E. N.; Sigman, M. S. Linear Free Energy Relationships (LFERs) in Asymmetric Catalysis. In Asymmetric Synthesis II: More Methods and Applications, Christmann, M.; Bräse, S., Eds. Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, 2012; pp 363–370.

4. Harper, K. C.; Bess, E. N.; Sigman, M. S. Multidimensional Steric Parameters in the Analysis of Asymmetric Catalytic Reactions. Nature Chem. 2012, 4, 366–374.

Pre-Graduate Work:

3. Sherwood, K.; Sugerman, S.; Bossart, P.; Bledsoe, J.; Barton, E.; Bernhisel, K.; Bess, E.; Madsen, T. EDOU Staffing by PAs: What are the Effects on Patient Outcomes? JAAPA 2011, 24, 31–37.

2. Lingenfelter, E. M.; Davis, V.; Larrabee, K.; Bess, E.; Canning, P.; Madsen, T. 192: Cholesterol Screening and Intervention Compliance In Chest Pain Patients In the Emergency Department Observation Unit Setting. Ann. Emerg. Med. 2010, 56, S64.

1. Bledsoe, J.; Hamilton, D.; Bess, E.; Holly, J.; Sturges, Z.; Madsen, T. Treatment of Low-risk Pulmonary Embolism Patients in a Chest Pain Unit. Crit. Pathw. Cardiol. 2010, 9, 212–215.

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